Eradication of Salmonella Typhimurium infection in a murine model of typhoid fever with the combination of probiotic Lactobacillus fermentum ME-3 and ofloxacin

Eradication of Salmonella Typhimurium infection in a murine model of typhoid fever with the combination of probiotic Lactobacillus fermentum ME-3 and ofloxacin

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Abstract Background The aim of the study was to detect whether in experimental Salmonella enterica Typhimurium infection the probiotic Lactobacillus fermentum ME-3 metabo 15-gauge finish nailer cordless in combination with fluoroquinolone therapy would eradicate S.Typhimurium, prevent the development of liver and spleen granulomas and improve the indices of oxidative stress in the ileum mucosa.The selected bacteriological, histological and biochemical methods were applied.

Results Combined treatment with L.fermentum ME-3 and ofloxacin eradicated Salmonella Typhimurium from blood, ileum and liver, decreased the number of animals with liver and spleen granulomas and reduced the value of lipid peroxides in here the ileum mucosa.Higher total counts of intestinal lactobacilli in all experimental groups were associated with the absence of liver granulomas.

Conclusion The antimicrobial and antioxidative probiotic L.fermentum ME-3 combined with ofloxacin enhances the eradication of experimental S.Typhimurium infection.

These observations on probiotic and antimicrobial co-action may serve as basis to develop new strategies for treatment of invasive bacterial infections of the gut.